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SPINOCEREBELLAR ATAXIA 3 PROTEIN
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DeCS
Descriptor
English
:
Ataxin-3
Descriptor
Spanish
:
Ataxina-3
Descriptor
Portuguese
:
Ataxina-3
Synonyms
English
:
ATXN3 Protein
Ataxin-3 Protein
Machado-Joseph Disease Protein
SCA3 Protein
Spinocerebellar Ataxia 3 Protein
Ataxin 3
Ataxin 3 Protein
Machado Joseph Disease Protein
Tree Number:
D08.811.037.250
D12.776.631.069.875
D12.776.660.075.875
Definition
English
:
A deubiquitinating enzyme of the
ATAXINS
family
. It functions in protein
homeostasis
, GENETIC TRANSCRIPTION;
CYTOSKELETON
regulation, and MYOGENESIS. CAG
TRINUCLEOTIDE REPEAT EXPANSION
in the
Ataxin-3
gene coding region is associated with spinocerebellar ataxia-3 (
MACHADO-JOSEPH DISEASE
).
See Related
English
:
Spinocerebellar Ataxias
History Note
English
:
2016 (1995)
Allowable Qualifiers
English
:
AD
administration & dosage
AE
adverse effects
AG
agonists
AN
analysis
AI
antagonists & inhibitors
BI
biosynthesis
BL
blood
CF
cerebrospinal fluid
CS
chemical synthesis
CH
chemistry
CL
classification
CT
contraindications
DF
deficiency
DE
drug effects
EC
economics
GE
genetics
HI
history
IM
immunology
IP
isolation & purification
ME
metabolism
PK
pharmacokinetics
PD
pharmacology
PH
physiology
PO
poisoning
RE
radiation effects
SE
secretion
ST
standards
SD
supply & distribution
TU
therapeutic use
TO
toxicity
UL
ultrastructure
UR
urine
Record Number:
55958
Unique Identifier:
D000067699
Occurrence in VHL
:
Similar:
DeCS
CID-10
SciELO
LILACS
LIS